1,189 research outputs found
Time Variability in the X-ray Nebula Powered by Pulsar B1509-58
We use new and archival Chandra and ROSAT data to study the time variability
of the X-ray emission from the pulsar wind nebula (PWN) powered by PSR B1509-58
on timescales of one week to twelve years. There is variability in the size,
number, and brightness of compact knots appearing within 20" of the pulsar,
with at least one knot showing a possible outflow velocity of ~0.6c (assuming a
distance to the source of 5.2 kpc). The transient nature of these knots may
indicate that they are produced by turbulence in the flows surrounding the
pulsar. A previously identified prominent jet extending 12 pc to the southeast
of the pulsar increased in brightness by 30% over 9 years; apparent outflow of
material along this jet is observed with a velocity of ~0.5c. However, outflow
alone cannot account for the changes in the jet on such short timescales.
Magnetohydrodynamic sausage or kink instabilities are feasible explanations for
the jet variability with timescale of ~1.3-2 years. An arc structure, located
30"-45" north of the pulsar, shows transverse structural variations and appears
to have moved inward with a velocity of ~0.03c over three years. The overall
structure and brightness of the diffuse PWN exterior to this arc and excluding
the jet has remained the same over the twelve year span. The photon indices of
the diffuse PWN and possibly the jet steepen with increasing radius, likely
indicating synchrotron cooling at X-ray energies.Comment: accepted to ApJ, 14 pages, 8 figure
Use of generic and condition-specific measures of health-related quality of life in NICE decision-making: systematic review, statistical modelling and survey.
© Queenâs Printer and Controller of HMSO 2014Background: The National Institute for Health and Care Excellence recommends the use of generic preference-based measures (GPBMs) of health for its Health Technology Assessments (HTAs). However, these data may not be available or appropriate for all health conditions.
Objectives: To determine whether GPBMs are appropriate for some key conditions and to explore
alternative methods of utility estimation when data from GPBMs are unavailable or inappropriate.
Design: The project was conducted in three stages: (1) A systematic review of the psychometric properties of three commonly used GPBMs [EQ-5D, SF-6D and Health Utilities Index Mark 3 (HUI3)] in four broadly defined conditions: visual impairment, hearing impairment, cancer and skin conditions. (2) Potential modelling approaches to âmapâ EQ-5D values from condition-specific and clinical measures of health [European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy â General Scale (FACT-G)] are compared for predictive ability and goodness of fit using two separate data sets. (3) Three potential extensions to the EQ-5D are developed as âbolt-onâ items relating to hearing, tiredness and vision. They are valued using the time trade-off method. A second valuation study is conducted to fully value the EQ-5D with and without the vision bolt-on item in an additional sample of 300 people.
Main outcome measures: Comparisons of EQ-5D, SF-6D and HUI3 in four conditions with various generic and condition-specific measures. Mapping functions were estimated between EORTC QLQ-C30 and FACT-G with EQ-5D. Three bolt-ons to the EQ-5D were developed: EQ + hearing/vision/tiredness. A full valuation study was conducted for the EQ + vision.
Results: (1) EQ-5D was valid and responsive for skin conditions and most cancers; in vision, its performance varied according to aetiology; and performance was poor for hearing impairments. The HUI3 performed well for hearing and vision disorders. It also performed well in cancers although evidence was limited and there was no evidence in skin conditions. There were limited data for SF-6D in all four conditions and limited evidence on reliability of all instruments. (2) Mapping algorithms were estimated to predict EQ-5D values from alternative cancer-specific measures of health. Response mapping using all the domain scores was the best performing model for the EORTC QLQ-C30. In an exploratory analysis, a limited dependent variable mixture model performed better than an equivalent linear model. In the full analysis for the FACT-G, linear regression using ordinary least squares gave the best predictions followed by the tobit model. (3) The exploratory valuation study found that bolt-on items for vision, hearing and tiredness had a significant impact on values of the health states, but the direction and magnitude of differences depended on the severity of the health state. The vision bolt-on item had a statistically significant impact on EQ-5D health state values and a full valuation model was estimated.
Conclusions: EQ-5D performs well in studies of cancer and skin conditions. Mapping techniques provide a solution to predict EQ-5D values where EQ-5D has not been administered. For conditions where EQ-5D was found to be inappropriate, including some vision disorders and for hearing, bolt-ons provide a promising solution. More primary research into the psychometric properties of the generic preference-based measures is required, particularly in cancer and for the assessment of reliability. Further research is needed for the development and valuation of bolt-ons to EQ-5D.UK Medical Research Council (MRC) as part of the MRC-NIHR methodology research programme (reference G0901486
Improving the measurement of QALYs in dementia: developing patient- and carer-reported health state classification systems using Rasch analysis
Objectives: Cost-utility analysis is increasingly used to inform resource allocation. This requires a means of valuing health states before and after intervention. Although generic measures are typically used to generate values, these do not perform well with people with dementia. We report the development of a health state classification system amenable to valuation for use in studies of dementia, derived from the DEMQOL system, a measure of health-related quality of life in dementia by patient self-report (DEMQOL) and carer proxy-report (DEMQOL-Proxy). Methods: Factor analysis was used to determine the dimensional structure of DEMQOL and DEMQOL-Proxy. Rasch analysis was subsequently used to investigate item performance across factors in terms of item-level ordering, functioning across subgroups, model fit and severity-range coverage. This enabled the selection of one item from each factor for the classification system. A sample of people with a diagnosis of mild/moderate dementia (n=644) and a sample of carers of those with mild/moderate dementia (n=683) were used. Results: Factor analysis found different 5-factor solutions for DEMQOL and DEMQOL-Proxy. Following item reduction and selection using Rasch analysis, a 5-dimension classification for DEMQOL and a 4-dimension classification for DEMQOL-Proxy were developed. Each item contained 4 health state levels. Conclusion: Combining Rasch and classical psychometric analysis is a valid method of selecting items for dementia health state classifications from both the patient and carer perspectives. The next stage is to obtain preference weights so that the measure can be used in the economic evaluation of treatment, care and support arrangements for dementia.quality adjusted life years; health related quality of life; Rasch analysis; preference-based measures of health; health states; dementia
Chandra observations of the pulsar wind nebula in SNR G0.9+0.1
We present observations with the Chandra X-ray Observatory of the pulsar wind
nebula (PWN) within the supernova remnant G0.9+0.1. At Chandra's high
resolution, the PWN has a clear axial symmetry; a faint X-ray point source
lying along the symmetry axis possibly corresponds to the pulsar itself. We
argue that the nebular morphology can be explained in terms of a torus of
emission in the pulsar's equatorial plane and a jet directed along the pulsar
spin axis, as is seen in the X-ray nebulae powered by other young pulsars. A
bright clump of emission within the PWN breaks the axisymmetry and may
correspond to an intermediate-latitude feature in the pulsar wind.Comment: 5 pages, 2 embedded EPS figures, uses emulateapj.sty . Accepted to
ApJ Letter
Communications Biophysics
Contains research objectives and reports on two research projects
English law for the surgeon II: Clinical negligence
Traditionally, in the United Kingdom and Europe, the surgeon was generally not troubled by litigation from patients presenting as elective as well as emergency cases, but this aspect of custom has changed. Litigation by patients now significantly affects surgical practice and vicarious liability often affects hospitals. We discuss some fundamental legal definitions, a must to know for a surgeon, and highlight some interesting cases
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